YM 905
Solifenacin
CAS: 242478-37-1
Molecular Formula: C23H26N2O2
YM 905 - Names and Identifiers
| Name | Solifenacin |
| Synonyms | YM 905 Solif·Nacin Solifenacin Unii-A8910sqj1u 4R-Hydroxy Solifenacin Solifenacin intermediate 4R-Hydroxy Solifenacin N-Oxide (1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate (3R)-1-azabicyclo[2.2.2]oct-3-yl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate [(8R)-1-azabicyclo[2.2.2]octan-8-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate 3,4-dihydro-1-phenyl-(1S)-2(1H)-Isoquinolinecarboxylic acid (3R)-1-azabicyclo[2.2.2]oct-3-yl ester 2(1H)-Isoquinolinecarboxylicacid, 3,4-dihydro-1-phenyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester, (1S)- |
| CAS | 242478-37-1 |
| InChI | InChI=1/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1 |
YM 905 - Physico-chemical Properties
| Molecular Formula | C23H26N2O2 |
| Molar Mass | 362.47 |
| Density | 1.24±0.1 g/cm3(Predicted) |
| Boling Point | 505.5±50.0 °C(Predicted) |
| Flash Point | 259.5°C |
| Vapor Presure | 2.41E-10mmHg at 25°C |
| pKa | 9.03±0.33(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.648 |
| In vitro study | Solifenacin is a novel muscarinic receptor antagonist with pK i s of 7.6±0.056, 6.9±0.034 and 8.0±0.021 for M1, M2 and M3 receptors, respectively. In murine submandibular gland cells, the antagonistic effects of 100 nM Solifenacin and oxybutynin on Ca 2+ mobilization evoked by varying doses of carbachol (CCh) are examined. Solifenacin does not shift the CCh dose-activation curve in a parallel manner whereas oxybutynin shows insurmountable antagonism. The pK b values are obtained as 7.4±0.17 for Solifenacin and 8.8±0.21 for oxybutynin. |
| In vivo study | Solifenacin reduces bladder responses by 40% at a dose of 210 nmol/kg (0.1 mg/kg) and abolishes them at 2100 nmol/kg (1 mg/kg). In contrast, its inhibitory effects on salivary and cardiac responses are only slight at 630 nmol/kg (0.3 mg/kg), and reach 66% and 49%, respectively, at 2100 nmol/kg (1 mg/kg). At doses of 63 and 210 nmol/kg (0.03 and 0.1 mg/kg), Solifenacin slightly increases saliva secretion. Solifenacin (0.01 to 0.3 mg/kg i.v.) dose-dependently increases bladder capacity and voided volume at doses of 0.03 mg/kg i.v. or more, but does not affect residual volume or micturition pressure at any dose tested. |
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Multiple SpecificationsSpot supply
Product Name: YM905 free base Visit Supplier Webpage Request for quotationCAS: 242478-37-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Solifenacin Visit Supplier Webpage Request for quotationCAS: 242478-37-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Solifenacin Visit Supplier Webpage Request for quotationCAS: 242478-37-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Solifenacin Visit Supplier Webpage Request for quotationCAS: 242478-37-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
YM 905
113367-94-5
(p-acetylphenoxy)acetic acid
3-Hydroxy-6,6-Dimethyl-1-Heptene-4-Yne
2-乙氧基萘-1-硼酸
24024-09-7
113367-94-5
(p-acetylphenoxy)acetic acid
3-Hydroxy-6,6-Dimethyl-1-Heptene-4-Yne
2-乙氧基萘-1-硼酸
24024-09-7